RESUMO
Type A insulin resistance (IR) syndrome is a very uncommon genetic disorder affecting the insulin receptor (INSR) gene, characterized by severe IR without the presence of obesity. Patients with this condition will eventually develop diabetes, presenting a variable response to insulin-sensitizers, such as metformin and thiazolidinediones, and high doses of insulin. We report for the first time the results of the use of combination therapy with a glucagon-like peptide-1 receptor agonist and a sodium-glucose cotransporter 2 inhibitor for the treatment of diabetes in the context of type A IR syndrome.
Assuntos
Diabetes Mellitus , Resistência à Insulina , Compostos Benzidrílicos , Peptídeos Semelhantes ao Glucagon , Glucosídeos , Humanos , InsulinaRESUMO
Introducción. Se estudia la relación entre la homocisteína y la actividad física, teniendo en cuenta la asociación con otros factores como el sexo, la edad, la vitamina B12 y el ácido fólico. Método. Muestra de 40 adultos, trabajadores del Hospital Universitario Virgen de la Victoria de Málaga. La actividad física se midió mediante podómetro y por encuesta retrospectiva. Resultados. En la muestra global, la homocisteína está relacionada inversamente con la actividad física, medida mediante podómetro, con el sexo femenino, con el ácido fólico y directamente con la edad. En el análisis multivariante, la asociación significativa permanece únicamente con el sexo. Las mujeres muestran más actividad física diaria y valores de homocisteína más bajos, que en los varones. Los datos de ejercicio físico obtenidos por encuesta no revelan ninguna asociación, aunque los varones tiene una tendencia, no significativa, a realizar más ejercicio físico estructurado. Conclusiones. A la vista de las referencias bibliográficas existentes, se comentan los resultados con la finalidad práctica de matizar las recomendaciones que se realizan a la población en el ejercicio físico con fines preventivos y promotores de salud (AU)
Introduction. We examined the relationship between homocysteine levels and physical activity, taking into account other factors such as gender, age, folic acid and vitamin B12. Methods. The sample included 40 adults, workers of the Hospital Universitario Virgen de la Victoria of Málaga (Spain). The physical activity was measured by pedometer and by retrospective questionnaire. Results. In the overall sample homocysteine is inversely related with physical activity, measured by pedometer, but not when done by a retrospective questionnaire on structured physical exercise, with the female sex and with the folic acid levels, and was directly related with the age. Multivariant step by step statistical study shows that the significany association remains only with gender. Women have higher values of homocysteine than men. The women also accomplished higher physical activity than men, when the pedometer results were calculated, but not by the results of the retrospective questionnaire. In the last case, the values were higher, but with no significant differences between sexes. Conclusions. These results suggest, according to the literature, the need for qualifying the interplay of the different existing factors when making recommendations for the population to carry out physical exercise in order to improve their health status (AU)
